Role Of SULT1A1 Mutations In Minoxidil Activation And Detection Of Non Responders By Trichogene-Minoxidil Response Test (MRT )

The recommended dosage for minoxidil in the treatment of androgenetic alopecia (AGA), also known as male or female pattern baldness, varies depending on the formulation used. Minoxidil is available as a topical solution or foam that is applied directly to the scalp.

For the 5% topical solution, the recommended dosage is 1 mL applied twice daily to the affected areas of the scalp. It is important to spread the solution evenly and massage it into the scalp with your fingertips to ensure that it reaches the hair follicles.

For the 5% foam formulation, the recommended dosage is half a capful (about 1 gram) applied twice daily to the affected areas of the scalp. Again, it is important to spread the foam evenly and massage it into the scalp with your fingertips.

It is important to use minoxidil consistently as directed by your healthcare provider, as it may take several months of regular use before any noticeable improvement in hair growth is seen. Additionally, if you stop using minoxidil, any benefits that have been gained may be lost within a few months.

Sulfotransferases are a family of enzymes that are involved in the transfer of a sulfonate group from a donor molecule to an acceptor molecule. This process, known as sulfation, plays a critical role in the metabolism and elimination of many drugs, hormones, and xenobiotics in the body. There are several different forms of sulfotransferase enzymes in the body, each of which has a different substrate specificity and tissue distribution.

The SULT1A1 gene is one of the most studied members of the sulfotransferase enzyme family. It encodes for the SULT1A1 enzyme, which is primarily expressed in the liver and plays a role in the metabolism of a wide range of drugs, hormones, and xenobiotics. The SULT1A1 enzyme is involved in the sulfation of many endogenous compounds, such as estrogen, androgens, and thyroid hormones, as well as many drugs, including minoxidil.

SULT1A1 is a gene that encodes for a sulfotransferase enzyme involved in the metabolism of drugs, hormones, and xenobiotics in the body. SULT1A1*2 is a genetic variant of the SULT1A1 gene that has been associated with altered activity of the enzyme.Studies have shown that individuals who carry one or two copies of the SULT1A1*2 variant may have reduced activity of the sulfotransferase enzyme, which can affect the metabolism of drugs that are substrates for this enzyme, including minoxidil.

One study published in the Journal of the American Academy of Dermatology found that individuals with the SULT1A12 variant had significantly lower plasma concentrations of the active metabolite of minoxidil compared to those without the variant. This suggests that individuals with the SULT1A12 variant may require higher doses of minoxidil to achieve the same therapeutic effect.

Trichogene an Indian based startup company introduced Minoxidil Response Test to determine non responders of minoxidil using simple buccal swab sample.For more information about MRT and to book test  please visit www.trichogene.in

Read More: Lexicon MILE Launches ‘CAPSTONE’ To Bridge The Gap Between Real-Time Work And Classroom Teaching

In general, individuals who are considering using minoxidil should speak with their healthcare provider about any genetic variants or other factors that may affect their metabolism of the drug, and should follow their healthcare provider’s instructions for dosing and monitoring.